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Business 100 - 2025

Brian O’Callaghan

Deep Genomics

Brian O’Callaghan joins Deep Genomics as (CEO) and board member, with more than 30 years experience as a senior life science executive with extensive knowledge within the biotech, big pharma and clinical research organization (CRO) sectors. Previously, he held CEO positions at ObsEva SA, Petra Pharma, Acucela, Sangart and BioPartners.  Earlier in his career, Brian held multiple senior management positions at Pfizer, Merck Serono, Novartis, Covance and NPS Pharmaceuticals. 

In his role at Deep Genomics, Brian will lead the company into its next phase of growth, as it transitions from a research organization via its AI platform, into a forward-integrated drug development biotechnology company with innovative RNA-based products moving into multiple clinical trials. 

He received a Marketing Diploma from the Marketing Institute of Ireland and a Master of Business Administration (MBA) from the Henley Business School at the University of Reading.

Outside of work, Brian has had many other interests, including serving as Chairman of San Diego Youth GAA, Chairman of both The Farmers Insurance Open and the US Open at Torrey Pines, and Chairman of a number of charitable nonprofit organizations.

Brian lives in San Diego with his wife Fiona, who is also from Cork and whom he met just after high school. They have three grown sons and are now enjoying life as empty nesters.

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